Detection of the high-level aminoglycoside resistance gene aph(2 '')-Ib inEnterococcus faecium

Authors
Kao, SJ You, L Clewell, DB Donabedian, SM Zervos, MJ Petrin, J Shaw, KJ Chow, JW
Citation
Sj. Kao et al., Detection of the high-level aminoglycoside resistance gene aph(2 '')-Ib inEnterococcus faecium, ANTIM AG CH, 44(10), 2000, pp. 2876-2879
Citations number
21
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
10
Year of publication
2000
Pages
2876 - 2879
Database
ISI
SICI code
0066-4804(200010)44:10<2876:DOTHAR>2.0.ZU;2-V
Abstract
A new high-level gentamicin resistance gene, designated aph(2")-Ib, was clo ned from Enterococcus faecium SF11770. The deduced amino acid sequence of t he 897-bp open reading frame of aph(2")-Ib shares homology with the aminogl ycoside-modifying enzymes AAC(6')APH(2"), APH(2")-Ic, and APH(2")-Id. The o bserved phosphotransferase activity is designated APH(2")-Ib.