The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region

Authors
Xiong, A Gottman, A Park, C Baetens, M Pandza, S Matin, A
Citation
A. Xiong et al., The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region, ANTIM AG CH, 44(10), 2000, pp. 2905-2907
Citations number
13
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
10
Year of publication
2000
Pages
2905 - 2907
Database
ISI
SICI code
0066-4804(200010)44:10<2905:TEPRTE>2.0.ZU;2-N
Abstract
EmrR negatively regulates the transcription of the multidrug resistance pum p-encoding operon, emrRAB, by binding to its regulatory region. The binding site spans the promoter and the downstream sequence up to the transcriptio nal start site of the operon. Structurally unrelated drugs that induce the pump interfere with this binding.