Multiple-antibiotic resistance mediated by structurally related IncL/M plasmids carrying an extended-spectrum beta-lactamase gene and a class 1 integron

Citation
L. Villa et al., Multiple-antibiotic resistance mediated by structurally related IncL/M plasmids carrying an extended-spectrum beta-lactamase gene and a class 1 integron, ANTIM AG CH, 44(10), 2000, pp. 2911-2914
Citations number
29
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
10
Year of publication
2000
Pages
2911 - 2914
Database
ISI
SICI code
0066-4804(200010)44:10<2911:MRMBSR>2.0.ZU;2-5
Abstract
A conjugative IncL/M plasmid (pSEM) conferring resistance to gentamicin, am ikacin, kanamycin, sulfonamides, and expanded-spectrum cephalosporins was f ound in pathogenic strains of Salmonella enterica serotype Typhimurium. Res istance to aminoglycosides was encoded by a sul1-type class 1 integron (In- t3). An extended-spectrum beta-lactamase gene, bla(SHV-5), was identified 3 .5 kb downstream of the integrase (intI1) gene of In-t3. Nucleotide sequenc e analysis of the 5.3-kb bla(SHV-5)-In-t3 region of pSEM highlighted striki ng similarities with IncL/M plasmids isolated from nosocomial gram-negative pathogens, conferring resistance to expanded-spectrum cephalosporins and a minoglycosides.