Itraconazole-amphotericin B antagonism in Aspergillus fumigatus: an E-test-based strategy

Authors
Kontoyiannis, DP Lewis, RE Sagar, N May, G Prince, RA Rolston, KVI
Citation
Dp. Kontoyiannis et al., Itraconazole-amphotericin B antagonism in Aspergillus fumigatus: an E-test-based strategy, ANTIM AG CH, 44(10), 2000, pp. 2915-2918
Citations number
14
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
10
Year of publication
2000
Pages
2915 - 2918
Database
ISI
SICI code
0066-4804(200010)44:10<2915:IBAIAF>2.0.ZU;2-O
Abstract
We examined an E-test-based strategy for testing the combination of itracon azole and amphotericin B, the latter given either sequentially or concomita ntly, in isolates of Aspergillus fumigatus. An antagonistic interaction bet ween the two drugs was noted, especially with the sequential administration of amphotericin B. This in vitro antagonism was reversible.