Bioavailability of praziquantel increases with concomitant administration of food

Authors
Castro, N Medina, R Sotelo, J Jung, H
Citation
N. Castro et al., Bioavailability of praziquantel increases with concomitant administration of food, ANTIM AG CH, 44(10), 2000, pp. 2903-2904
Citations number
10
Categorie Soggetti
Microbiology
Journal title
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
ISSN journal
00664804 → ACNP
Volume
44
Issue
10
Year of publication
2000
Pages
2903 - 2904
Database
ISI
SICI code
0066-4804(200010)44:10<2903:BOPIWC>2.0.ZU;2-6
Abstract
In the present study we found that after a single oral dose of 1,800 mg of praziquantel, following a high-lipid diet and a high-carbohydrate diet, the maximum levels in plasma increased 243 and 515% and the area under the pla sma concentration curve from 0 to 8 h increased 180 and 271%, respectively.