This paper briefly reviews the basic principles of several clinical applica
tions of electrical stimulation for therapeutic purposes. It is intended to
facilitate the integration of electrical stimulation into routine clinical
practice by clarifying the terminology and standard conventions of the fie
ld, explaining the delivery capabilities of common electrical stimulators c
ommercially available for clinical use, summarizing several examples of evi
dence-based therapeutic applications, and providing guidelines for selectio
n of most commonly used treatment parameters. Rather than an exhaustive sur
vey of the field, the presentation touches broadly on guidelines for use of
transcutaneous electrical stimulation employing surface electrodes for the
purposes of analgesia (TENS), drug delivery (iontophoresis), or neuromuscu
lar rehabilitation (NMES), as well as other selected clinical applications.
The paper is a general review of common clinical practices of electrothera
py and should serve as an introduction to the important factors for clinici
ans to consider when contemplating electrical stimulation as a treatment op
tion.