Apolipoprotein E4 phenotype increases non-fasting serum triglyceride concentration in infants - the STRIP study

As genetically determined apolipoprotein E (apo E) phenotypes influence ser um cholesterol concentration, we analysed whether serum triglyceride values are also affected by the apo E phenotypes in infants. Non-fasting serum tr iglyceride values were measured in 7- and 13-month-old participants in the STRIP project, a randomised, prospective trial aimed at reducing children's exposure to known atherosclerosis risk factors (n = 1062). The mean +/- S. D. non-fasting serum triglyceride concentrations in 7-month-old infants wit h apo E4/4 (n = 36), E3/4 (n = 209), E3/3 (n = 412), and E2/3 (n = 66) were 2.05 +/- 1.24, 1.81 +/- 0.90, 1.63 +/- 0.90, and 1.71 +/- 0.83 mmol/l, res pectively. Triglyceride concentrations were higher in infants with apo E4/4 or 3/4 than in those with apo E3/3 (P-value for difference 0.01 and 0.009, respectively). The apo E phenotype similarly influenced non-fasting serum triglyceride concentrations at the age of 13 months. The differences in ser um triglyceride values in apo E4(+) infants (apo E3/4 and 4/4 infants combi ned) and apo E4(-) infants (apo E2/3 and 3/3 infants combined) occurred ind ependently of the relative weight of the infant, milk type used at 7 months of age (breast milk or formula), and time elapsed from the previous meal. To conclude, apo E phenotypes regulate non-fasting serum triglyceride value s in healthy infants. Apo E3/4 and apo E4/4 predispose infants to higher va lues than apo E3/3 phenotype, suggesting that the epsilon 4 allele may incr ease atherosclerosis risk also via it's effect on postprandial triglyceride metabolism. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.