Icd. Westendorp et al., The effect of hormone replacement therapy on arterial distensibility and compliance in perimenopausal women: a 2-year randomised trial, ATHEROSCLER, 152(1), 2000, pp. 149-157
Citations number
57
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
A single centre randomised placebo-controlled trial was performed to assess
the 2-year effects of hormone replacement therapy compared to placebo on m
echanical arterial properties in 99 perimenopausal women recruited from the
general population. The trial was double-blind with respect to a sequentia
l combined regimen of oral 17 beta-oestradiol and desogestrel (17 beta E-2-
D) and the placebo group and open with respect to combination of conjugated
equine oestrogens and norgestrel (CEE-N). At baseline, distensibility and
compliance of the common carotid artery were measured non-invasively with B
-mode ultrasound and a vessel wall movement detector system, and the disten
sibility coefficient (DC) and compliance coefficient (CC) were calculated.
Measurements were repeated after 6 and 24 months. Change in DC and CC in tr
eatment groups was compared to placebo. After 24 months, changes for 17 bet
a E-2-D compared to placebo were - 1.4 x 10(-3)/kPa (95% CI - 4.4; 1.7, P =
0.39) for DC and 0.26 mm(2)/kPa (95% CI - 0.01; 0.53, P = 0.07) for CC. Ch
anges for CEE-N compared to placebo were 0.4 x 10(-3)/kPa (95% CI - 1.0; 1.
9, P = 0.79) and 0.11 mm(2)/kPa (95% CI - 0.14; 0.37, P = 0.40). For systol
ic blood pressure (SBP), diastolic blood pressure (DBP) and arterial lumen
diameter no changes were found. In this study no significant differences in
changes in distensibility and compliance were found between perimenopausal
women using 17 beta E-2-D or CEE-N and women using placebo after 6 and 24
months. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.