Md. Boyano et al., Soluble interleukin-2 receptor, intercellular adhesion molecule-1 and interleukin-10 serum levels in patients with melanoma, BR J CANC, 83(7), 2000, pp. 847-852
Serum soluble interleukin-2 receptor (sIL-2R), intercellular adhesion molec
ule-1 (sICAM-1) and interleukin-10 (IL-10) have each been reported as usefu
l markers for melanoma progression. To evaluate the clinical relevance of t
hese three markers, we simultaneously analysed their serum levels in patien
ts with melanoma. A longitudinal study with a 3-year follow-up was performe
d and different stages of the disease were considered. Mean values of sIL-2
R were significantly higher than in normal controls in all stages and corre
lated with the disease progression. The prognosis of patients with levels >
529 U/ml of sIL-2R was significantly poorer than in patients with sIL-2R l
evels < 529 U/ml. Levels of sICAM-1 were also elevated in melanoma patients
, specially at the time of the metastatic disease. Serum IL-10 levels were
more frequently detectable in the patients that developed metastasis during
follow-up, and the prognosis of patients with detectable IL-10 levels was
significantly poorer than in those patients with IL-10 undetected levels. S
tatistical analysis based on Logistic and Cox regression models showed that
only sex, stage and sIL-2R value are factors significantly associated with
metastatic progression. Moreover, high levels of sIL-2R could be a risk fa
ctor for malignant progression in melanoma. (C) 2000 Cancer Research Campai
gn.