Soluble interleukin-2 receptor, intercellular adhesion molecule-1 and interleukin-10 serum levels in patients with melanoma

Citation
Md. Boyano et al., Soluble interleukin-2 receptor, intercellular adhesion molecule-1 and interleukin-10 serum levels in patients with melanoma, BR J CANC, 83(7), 2000, pp. 847-852
Citations number
34
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
BRITISH JOURNAL OF CANCER
ISSN journal
00070920 → ACNP
Volume
83
Issue
7
Year of publication
2000
Pages
847 - 852
Database
ISI
SICI code
0007-0920(200010)83:7<847:SIRIAM>2.0.ZU;2-M
Abstract
Serum soluble interleukin-2 receptor (sIL-2R), intercellular adhesion molec ule-1 (sICAM-1) and interleukin-10 (IL-10) have each been reported as usefu l markers for melanoma progression. To evaluate the clinical relevance of t hese three markers, we simultaneously analysed their serum levels in patien ts with melanoma. A longitudinal study with a 3-year follow-up was performe d and different stages of the disease were considered. Mean values of sIL-2 R were significantly higher than in normal controls in all stages and corre lated with the disease progression. The prognosis of patients with levels > 529 U/ml of sIL-2R was significantly poorer than in patients with sIL-2R l evels < 529 U/ml. Levels of sICAM-1 were also elevated in melanoma patients , specially at the time of the metastatic disease. Serum IL-10 levels were more frequently detectable in the patients that developed metastasis during follow-up, and the prognosis of patients with detectable IL-10 levels was significantly poorer than in those patients with IL-10 undetected levels. S tatistical analysis based on Logistic and Cox regression models showed that only sex, stage and sIL-2R value are factors significantly associated with metastatic progression. Moreover, high levels of sIL-2R could be a risk fa ctor for malignant progression in melanoma. (C) 2000 Cancer Research Campai gn.