MRI and CT in the differential diagnosis of pleural disease

Study objective: To explore the role of MRI in the differential diagnosis o f pleural disease. Patients: Forty-two patients with pleural disease were included. Method: Retrospective study. All patients were examined with both CT and MR I. The morphologic features of pleural lesions and magnetic resonance signa l intensity on T1-weighted, T2-weighted, and contrast-enhanced T1-weighted images were evaluated. Results: Mediastinal pleural involvement, circumferential pleural thickenin g, nodularity, irregularity of pleural contour, and infiltration of the che st wall and/or diaphragm were most suggestive of a malignant cause both on CT and MRI. Pleural calcification on CT was suggestive of a benign cause. C ontrary to what has been previously reported in the literature, neither on CT nor on MRI, pleural thickness > 1 cm revealed significant difference bet ween malignant and benign pleural disease (p > 0,05, chi(2) test). High sig nal intensity in relation to intercostal muscles on T2-weighted and/or cont rast-enhanced T1-weighted images was significantly suggestive for a maligna nt disease. Using morphologic features in combination with the signal inten sity features, MRI had a sensitivity of 100% and a specificity of 93% in th e detection of pleural malignancy. Conclusion: When signal intensity and morphologic features are assessed, MR I is more useful and therefore superior to CT in differentiation of maligna nt from benign pleural disease.