A full relativistic formalism is employed to derive the relativistic partic
le-hole and delta-hole excitation polarization insertion of pion propagator
in nuclear matter. The spin-isospin-dependent response function of nucleus
at high energy-momentum transfer is calculated with the nuclear matter app
roximation. The short range correlation effect, two-nucleon absorption and
nucleus form factor effects are included in the calculation. The position a
nd width of the resonance peak of the spin-isospin made are reproduced and
found to be coincident with experiment data. The position of the peak and i
ts width is sensitive to Landau-Migdal parameter g' which is about 0.6.