Synthesis and biological evaluation of new antiinflammatory 1-benzothiophene-2-carboxanilides

Authors
Svoboda, J Stadler, M Jandera, A Panajotova, V Kuchar, M
Citation
J. Svoboda et al., Synthesis and biological evaluation of new antiinflammatory 1-benzothiophene-2-carboxanilides, COLL CZECH, 65(7), 2000, pp. 1082-1092
Citations number
21
Categorie Soggetti
Chemistry
Journal title
COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS
ISSN journal
00100765 → ACNP
Volume
65
Issue
7
Year of publication
2000
Pages
1082 - 1092
Database
ISI
SICI code
0010-0765(200007)65:7<1082:SABEON>2.0.ZU;2-Q
Abstract
3-Substituted 1-benzothiophene-2-carboxanilides 2-5 and their corresponding sulfones 6-8 were synthesized. The antiinflammatory effect of compounds 2- 8 was evaluated in tests of LTB4 biosynthesis, carrageenin edema and ear in flammation. With the exception of 3-hydroxyamides 5a-5c, low inhibitory act ivities against COX and LT biosynthesis were observed.