Venous blood flow measurement by determination of change in venous hemoglobin saturation

Objective: To evaluate a method of measuring venous blood flow in vitro by using the Fick principle and change in saturation of venous blood and to ap ply the method to the clinical measurement of hepatic blood flow. Design: Experimental study using an in vitro model and clinical study for c ritically ill patients, Setting: Department of Anesthesiology and Intensive Care Medicine in Osaka City University Medical School, Model: Human blood deoxygenated by bubbling of nitrogen was circulated in a closed circuit at 10-120 mL/min by a roller pump. A fiber optic sensor was attached to the circuit for continuous monitoring of hemoglobin saturation , Patients: Eight critically ill patients, aged 54.3 +/- 15.1 yrs, were studi ed. Interventions: Hemoglobin saturation was changed in the in vitro study by t he injection of 0.2 mt of oxygenated blood, Signals from the optical fiber were analogue-digital converted and recorded in a computer, In the clinical study, an oximetry catheter was inserted into the inferior vena cava (IVC) via the femoral vein, Arterial blood (10 mt) was drawn from the radial art ery, and injected into the IVC. The changes in oxygen saturation in the ven ous blood were recorded. Measurements and Main Results: Blood flow was calculated using the fick pri nciple, assuming that all the injected blood passes through the sensor, In vitro estimation of blood flow was well correlated with the actual flow (r( 2) =.94). IVC blood flow was measured above and below the merging point of the hepatic vein, The difference of the two values was assumed to represent hepatic blood few. IVC blood flow was calculated by the same method as for the in vitro study. The blood flows in the IVC above and below the anastom osis with the hepatic vein were 2.82 +/- 0.56 (SD) L/min and 1.96 +/- 0.61 (SD) L/min, Average estimated hepatic blood flow was 0.86 L/min (range, 0.3 4-1.75 L/min), Conclusion:We examined the accuracy and reliability of this new method in t he present in vitro study, This method may be clinically useful for measuri ng hepatic blood flow.