Gemtuzumab ozogamicin - Treatment of acute myeloid leukemia

Citation
X. Rabasseda et al., Gemtuzumab ozogamicin - Treatment of acute myeloid leukemia, DRUG FUTURE, 25(7), 2000, pp. 686-692
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
DRUGS OF THE FUTURE
ISSN journal
03778282 → ACNP
Volume
25
Issue
7
Year of publication
2000
Pages
686 - 692
Database
ISI
SICI code
0377-8282(200007)25:7<686:GO-TOA>2.0.ZU;2-4
Abstract
Immunoglobulin G(4) (anti-[human CD33 (antigen)] [human-mouse monoclonal hP 67.6 gamma(4)-chain]), disulfide with human-mouse monoclonal hP67.6 kappa-c hain, dimer conjugated to [(1R,4Z,8S, 1 3E)-[8-[[2-O-[4-(acetylethylamino)- 2,4-dideoxy-3-O-methyl-alpha-L-threo-pentopyranosyl]-4,6-dideoxy-4-[[[2,6-d ideoxy-4-S-[4-[(6-deoxy-3-O-methyl-alpha-L-mannopyranosyl)oxy]-3-iodo-5,6-d imethoxy-2-methylbenzoyl]-4-thio-beta-D-ribo-hexopyranosyl]oxy]amino]-beta- D-glucopyranosyl]oxy]-13-[2- [[3-[[1-[4-(4-amino-4-oxobutoxy)phenyl]ethylid ene]hydrazino]-1,1-dimethyl-3-oxopropyl]dithio]ethylidene]-1-hydroxy-11-oxo bicyclo[7.3.1]trideca-4,9-diene-2,6-diyn-10-yl]carbamic acid methyl ester.