Jjb. Nevado et al., Voltammetric behavior of fluvoxamine using square-wave and adsorptive stripping square-wave techniques. Determination in pharmaceutical products, ELECTROANAL, 12(13), 2000, pp. 1059-1063
The behavior of fluvoxamine (FVX) was studied by square-wave techniques, le
ading to two methods for its determination in aqueous samples (pH 2.0 and 4
.7) and pharmaceuticals formulations. The application of the square-wave mo
de shows the determination of FVX between 2 x 10(-8) and 3 x 10(-6) mol L-1
.FVX gave an adsorptive stripping voltammetric peak at the hanging mercury
drop electrode at - 0.76 V, using an accumulation potential of - 0.50 V By
the stripping technique, FVX proved to be more sensitive, yielding signals
five times larger than those obtained by applying a square-wave scan withou
t the previous accumulation. The calibration plot to determine FVX was line
ar in the range 5 x 10(-9) and 1 x 10(-6)mol L-1 by stripping mode. The rel
ative standard deviations obtained for concentration levels of FVX as low a
s 1.5 x 10(-6) mol L-1 with square-wave was 3.54 % (n = 10) and for 6.0 x 1
0 (-7) mol L-1 with stripping square-wave was 2.39% (n = 10) in the same da
y. The two proposed methods (SW and SWAdSV) were applied to the determinati
on of fluvoxamine in two Spanish commercial product (Dumirox 50 and Dumirox
100) with very good recoveries respect to the labelled values.