NEUROVASCULAR [I-125] ET-1 BINDING-SITES ON HUMAN PERIPHERAL-NERVE

Authors
DASHWOOD MR THOMAS PK
Citation
Mr. Dashwood et Pk. Thomas, NEUROVASCULAR [I-125] ET-1 BINDING-SITES ON HUMAN PERIPHERAL-NERVE, Endothelium, 5(2), 1997, pp. 119
Citations number
10
Categorie Soggetti
Peripheal Vascular Diseas","Cell Biology
Journal title
Endothelium → ACNP
ISSN journal
10623329
Volume
5
Issue
2
Year of publication
1997
Database
ISI
SICI code
1062-3329(1997)5:2<119:N[EBOH>2.0.ZU;2-E
Abstract
[I-125]-ET-1 binding to human peripheral nerve was studied using a com bination of in vitro autoradiography and immunohistochemistry. Dense b inding was predominantly to ETA receptors located on smooth muscles ce lls of the neural microvessels and the perineurium, These results iden tify regions where locally-released ET-1 may affect neural vascular pe rfusion and play a pathophysiological role in certain conditions, such as diabetic neuropathy.