High resolution comparative genomic hybridisation analysis reveals imbalances in dyschromosomal patients with normal or apparently balanced conventional karyotypes

Authors
Kirchhoff, M Rose, H Maahr, J Gerdes, T Bugge, M Tommerup, N Tumer, Z Lespinasse, J Jensen, PKA Wirth, J Lundsteen, C
Citation
M. Kirchhoff et al., High resolution comparative genomic hybridisation analysis reveals imbalances in dyschromosomal patients with normal or apparently balanced conventional karyotypes, EUR J HUM G, 8(9), 2000, pp. 661-668
Citations number
12
Categorie Soggetti
Molecular Biology & Genetics
Journal title
EUROPEAN JOURNAL OF HUMAN GENETICS
ISSN journal
10184813 → ACNP
Volume
8
Issue
9
Year of publication
2000
Pages
661 - 668
Database
ISI
SICI code
1018-4813(200009)8:9<661:HRCGHA>2.0.ZU;2-C
Abstract
A sensitive technique is needed for screening whole genome imbalances in dy schromosomal patients when C-banding shows normal karyotypes or apparently balanced translocations. In this study we performed highly sensitive compar ative genomic hybridisation analysis on a number of such cases and revealed chromosomal imbalances in all.