Characterization of clinical isolates of group C and G streptococci on thebasis of protein G gene

Treatment of human group C and G streptococci with cyanogen bromide results in solubilization of surface protein G molecules. Strain-to-strain variati on in the quanity, molar mass and functional activity of protein G extracte d from representative group C and G isolates led to the identification of t hree structurally and functionally distinct forms of the protein. Using dif ferent molecular biological approaches it was possible to determine the gro up of streptococci (C or G), or the quantity of IgG and HSA domains.