Recombinant FVIIa (NovoSeven) continuous infusion and total hip replacement in patients with haemophilia and high titre of inhibitors to FVIII: experience of two cases

In this report we describe our experience of total hip replacement in two p atients with severe haemophilia A and high titres of inhibitors to FVIII. W e used rFVIIa replacement therapy by continuous infusion to perform the sur gery. The total amount of rFVIIa used in these two patients was very simila r but the manner of administration was quite different. In our experience, it is an advantage to use a higher dose for shorter periods than a lower do se for a longer treatment period. Tranexamic acid by continuous infusion, a nd parallel saline infusion were useful for good haemostasis and avoided lo cal thrombophlebitis in the side of rFVIIa infusion.