The exact etiology of myocardial infarction remains unknown in a majority o
f the patients with normal coronary arteries. Those who smoke cigarettes an
d use cocaine are more prone to have this condition. The possible mechanism
s underlying myocardial infarction with normal coronary arteries are hyperc
oagulable states, coronary embolism, an imbalance between oxygen demand and
supply, nonatherosclerotic coronary diseases, coronary trauma, coronary va
sospasm, and coronary thrombosis. Myocardial infarction with normal coronar
y arteries primarily affects younger persons and is distinctly rare in jr p
atients older than 50 years. We describe a case of acute myocardial infarct
ion with normal coronary arteries in a 61-year-old woman who smoked cigaret
tes. The clinical perspectives and management of the myocardial infarction
with normal coronary arteries are discussed.