O. Mori et al., Adhesion molecule detection in a case of early cerebral malaria: Immunohistochemical and electron microscopic findings, HUMAN PATH, 31(9), 2000, pp. 1175-1178
Citations number
6
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research Diagnosis & Treatment
A case of early cerebral malaria caused by Plasmodium falciparum was studie
d. P-selectin glycoprotein ligand 1 (PL1) was detected along the inner surf
ace of the infected red blood cells (IRBCs), which ordinarily are nor posit
ive for PL1 immunohistochemically, suggesting PL1 being the product of para
site. The electron microscopic finding showed granular deposits in the corr
esponding lesion, consistent with PLI deposition, in the IRBCs firmly attac
hed to the endothelium of small cerebral vessels. Most of the IRBCs were ro
und shaped as though they lost their capacity to change shape. The therapeu
tic strategy was expected against adhesion molecules such as PL1 and for ma
intaining or restoring the metamorphic capacity of IRBCs. Copyright (C) 200
0 by W.B. Saunders Company.