Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis

Authors
Hume, EBH Dajcs, JJ Moreau, JM O'Callaghan, RJ
Citation
Ebh. Hume et al., Immunization with alpha-toxin toxoid protects the cornea against tissue damage during experimental Staphylococcus aureus keratitis, INFEC IMMUN, 68(10), 2000, pp. 6052-6055
Citations number
28
Categorie Soggetti
Immunology
Journal title
INFECTION AND IMMUNITY
ISSN journal
00199567 → ACNP
Volume
68
Issue
10
Year of publication
2000
Pages
6052 - 6055
Database
ISI
SICI code
0019-9567(200010)68:10<6052:IWATPT>2.0.ZU;2-Y
Abstract
Alpha-toxin is a major virulence factor in Staphylococcus aureus keratitis. Active or passive immunization with alpha-toxin toroid could protect again st corneal damage. Results show that either form of immunization did not ki ll bacteria but did significantly protect against corneal pathology, especi ally epithelial erosion.