Clinical evidence for correlation of insufficient tissue oxygen supply (hypoxia) and tumor-associated proteolysis in squamous cell carcinoma of the head and neck

Authors
Stadler, P Feldmann, HJ Creighton, C Zeilhoffer, HF Zimmermann, V Schmitt, M Molls, M
Citation
P. Stadler et al., Clinical evidence for correlation of insufficient tissue oxygen supply (hypoxia) and tumor-associated proteolysis in squamous cell carcinoma of the head and neck, INT J B MAR, 15(3), 2000, pp. 235-236
Citations number
7
Categorie Soggetti
Oncology
Journal title
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
ISSN journal
03936155 → ACNP
Volume
15
Issue
3
Year of publication
2000
Pages
235 - 236
Database
ISI
SICI code
0393-6155(200007/09)15:3<235:CEFCOI>2.0.ZU;2-F
Abstract
Hypoxic tumors of patients with squamous cell carcinoma of the head and nec k show a consistent trend towards poor treatment outcome. We now report tha t tumor hypoxia in these patients is correlated with elevated antigen conte nt of the tumor-associated serine protease uPA (urokinase-type plasminogen activator), a marker of tumor cell invasion and metastasis.