An analysis of the effect of age on implantation rates

Purpose: To evaluate implantation rate as a function of age. Methods: A total of 1621 consecutive cycles of IVF were evaluated for impla ntation as a function of age at The New York Hospital/Cornell Medical Cente r. Results: An overall implantation rate of 23.3% (1328/5691) was found. The i mplantation rate as a function of age decreased in a nonlinear fashion. Imp lantation remained constant until the age of 35 and then decreased in a sig nificantly, linear fashion by 2.77% per year (P < 0.001, R-2 = 0.975). A fo rmula to predict implantation rates for a given age was developed: Implanta tion rate = 119.352 + (9.985 x Age - (0.164 x Age(2))). Conclusions: We have demonstrated that implantation rates remain constant u ntil the age of 35 at which time a linear decrease of 2.77% per year is obs erved.