Tissue reactions after subcutaneous and intraosseous implantation of mineral trioxide aggregate and ethoxybenzoic acid cement

Biocompatibility of mineral trioxide aggregate and ethoxybenzoic acid cemen t was investigated by subcutaneous and intraosseous implantation of the mat erials in rats. Tissue reactions were studied at 15, 30, and 60 days after implantation. Subcutaneous implantation of mineral trioxide aggregate initi ally elicited severe reactions with coagulation necrosis and dystrophic cal cification; the reactions, however, subsided to mostly moderate with time. Subcutaneous implantation of ethoxybenzoic acid cement initially elicited m ostly moderate reactions that subsided to mild in time. Osteogenesis was no t observed with either material upon subcutaneous implantation indicating t hat neither material is osteoinductive. Reactions to intraosseous implants of both materials were less intense than with subcutaneous implantation. Os teogenesis occurred in association with intraosseous implants indicating th at both materials are osteoconductive. (C) 2000 John Wiley & Sons, Inc.