Efficacy of open-label nefazodone treatment in patients with panic disorder

Fifteen patients with panic disorder participated in a la-week treatment tr ial with open-label nefazodone. Nefazodone was well-tolerated with minimal side effects; none of the patients reported sexual dysfunction, and only on e patient experienced weight gain. Although the response rate was lower tha n that found with most other antipanic medications, given its favorable sid e effect profile, nefazodone may be a good alternative for patients apprehe nsive about potential adverse drug reactions.