Fifteen patients with panic disorder participated in a la-week treatment tr
ial with open-label nefazodone. Nefazodone was well-tolerated with minimal
side effects; none of the patients reported sexual dysfunction, and only on
e patient experienced weight gain. Although the response rate was lower tha
n that found with most other antipanic medications, given its favorable sid
e effect profile, nefazodone may be a good alternative for patients apprehe
nsive about potential adverse drug reactions.