We contend that perceived discrimination has an independent effect on depre
ssion outcomes among adults of Mexican origin. Using a sample of 3,012 Mexi
can-origin respondents in Fresno, California in 1995/96 (ages 18-59) we inv
estigate the direct and moderating connections between perceived discrimina
tion, acculturative stress, and mental health (CES-D). We also investigate
the social patterning of perceived discrimination. While more highly accult
urated immigrant respondents were more likely to experience discrimination
than their less acculturated counterparts, move highly acculturated U.S. bo
rn respondents were less likely to experience discrimination. Discriminatio
n was directly related to depression, but this effect was moderated through
nativity/country of residence, English-language acculturation, sex, and co
untry of education variables. Moderate levels of legal status acculturative
stress were especially depressive for native-born U.S. residents.