Catalytic oxidative carbonylation of aliphatic secondary amines to tetrasubstituted ureas

Authors
McCusker, JE Qian, F McElwee-White, L
Citation
Je. Mccusker et al., Catalytic oxidative carbonylation of aliphatic secondary amines to tetrasubstituted ureas, J MOL CAT A, 159(1), 2000, pp. 11-17
Citations number
34
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL
ISSN journal
13811169 → ACNP
Volume
159
Issue
1
Year of publication
2000
Pages
11 - 17
Database
ISI
SICI code
1381-1169(20000922)159:1<11:COCOAS>2.0.ZU;2-1
Abstract
Secondary amines can be catalytically carbonylated to symmetrical tetrasubs tituted ureas using W(CO)(6) as the catalyst, I-2 as the oxidant, and CO as the carbonyl source. Preparation of the corresponding tetrasubstituted ure as from the aliphatic secondary amines HNR2 (R = C2HS, n-Bu, i-Pr, PhCH2) a nd HNRR' (R,R' = -(CH2)(4)-; -(CH2)(5)-; PhCH2, CH3) was achieved in modera te yields. Aromatic secondary amines are unreactive. (C) 2000 Elsevier Scie nce B.V. All rights reserved.