Chloroperoxidase-catalyzed chlorination of didechloroaglucovancomycin and vancomycin

Authors
Malnar, I Sih, CJ
Citation
I. Malnar et Cj. Sih, Chloroperoxidase-catalyzed chlorination of didechloroaglucovancomycin and vancomycin, J MOL CAT B, 10(6), 2000, pp. 545-549
Citations number
17
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
ISSN journal
13811177 → ACNP
Volume
10
Issue
6
Year of publication
2000
Pages
545 - 549
Database
ISI
SICI code
1381-1177(20001101)10:6<545:CCODAV>2.0.ZU;2-H
Abstract
The chloroperoxidase (CPO) from Caldariomyces fumago catalyzed the chlorina tion of didechloroaglucovancomycin and vancomycin in the presence of hydrog en peroxide and chloride ion. Chlorination of didechloroaglucovancomycin ha s afforded new derivatives, with one and two chlorine atoms attached onto t he aromatic ring of residue 7 of didechloroaglucovancomycin. Vancomycin was similarly chlorinated under the same conditions to furnish a new dichloro derivative. (C) 2000 Elsevier Science B.V. All rights reserved.