1,3-dipolar cycloaddition reaction of 5-substituted pyridazinones with nitrile imines: synthesis of pyrazolo[3,4-d]pyridazines

Authors
Krajsovszky, G Gaal, A Haider, N Matyus, P
Citation
G. Krajsovszky et al., 1,3-dipolar cycloaddition reaction of 5-substituted pyridazinones with nitrile imines: synthesis of pyrazolo[3,4-d]pyridazines, J MOL ST-TH, 528, 2000, pp. 13-18
Citations number
30
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
JOURNAL OF MOLECULAR STRUCTURE-THEOCHEM
ISSN journal
01661280 → ACNP
Volume
528
Year of publication
2000
Pages
13 - 18
Database
ISI
SICI code
0166-1280(20000825)528:<13:1CRO5P>2.0.ZU;2-I
Abstract
Reaction of 5-substituted-2-methyl-3 (2H)-pyridazinones with diarylnitrile imines generated in situ has been shown to afford diarylpyrazolo[3,4-d]pyri dazin-4(5H)-ones. Structures of the products were proved by nmr spectroscop y. Reactivity and regiochemistry were analyzed by FMO theory. (C) 2000 Else vier Science B.V. All rights reserved.