High-quality research and patient care: An overview of clinical trials

Background, One of the responsibilities of the dental profession is to prot ect and advance the well-being of the public through research of new pharma ceuticals and devices. The objective of this article is to present informat ion about the scientific and regulatory process involved in the design and execution of randomized clinical trials. Conclusions, Dentists willing to serve as investigators in clinical trials- from Phase 1 to Phase 2 or Phase 3-need to be aware of the two main documen ts that contain the majority of guidelines and regulations governing clinic al research: Title 21 of the U.S.Code of Federal Regulations and the guidel ines for good clinical practice put forth by the International Conference o n Harmonisation. Clinical Implications, Advancements in the frontiers of oral health science and the development of safe, innovative and effective treatment modalities are often the result of high-quality clinical research that is conducted b y dental professionals. Knowledge of the research process, professionalism, scientific integrity and a detailed execution of the research plan are all required elements for a successful outcome.