Three patients with fever, exanthem, headache, and central-nervous-system i
nvolvement were diagnosed with Rickettsia felis infection by specific PCR o
f blood or skin and seroconversion to surrogate Rickettsia antigens. Althou
gh R fells's relationship to other Rickettsia species is known and the path
ogenic potential of this clade is well documented, R felis's role as a path
ogen has not been fully understood.