Presence of human beta- and gamma-herpes virus DNA in Hodgkin's disease

Citation
Ca. Schmidt et al., Presence of human beta- and gamma-herpes virus DNA in Hodgkin's disease, LEUK RES, 24(10), 2000, pp. 865-870
Citations number
35
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA RESEARCH
ISSN journal
01452126 → ACNP
Volume
24
Issue
10
Year of publication
2000
Pages
865 - 870
Database
ISI
SICI code
0145-2126(200010)24:10<865:POHBAG>2.0.ZU;2-J
Abstract
Herpes Viruses have been implicated in the etiology of Hodgkin's disease (H D). We studied the prevalence of human cytomegalovirus (CMV), human herpes viruses type-6 (HHV-6), type-7 (HHV-7) and type 8 (HHV-8) DNA in up to 88 H odgkin's disease biopsies in comparison to Epstein-Barr virus (EBV) DNA by polymerase chain reaction (PCR). Non-Hodgkin lymphomas (NHL) and reactive l esions served as controls. CMV and HHV-6 were found in 8/86 (9%) and 11/88 (13%) HD cases, respectively, by nested primer PCR. Except for three cases harbouring HHV-6 type-B, only HHV-6 type-A was detected in HD. HHV-7 was ob served by nested PCR in 33/88 (38%) HD cases and was already detectable in 15/88 (17%) HD cases by a single-round PCR indicating elevated virus copy n umbers. Seven of these cases showed co-infection with HHV-6, and 11 cases w ere found to contain EBV DNA. 7/8 CMV-positive HD cases also harboured EBV DNA. HHV-8 DNA was not detected by single round or nested PCR in any HD cas e investigated. Thus, CMV, HHV-6, and HHV-7 were present in small proportio ns of HD cases, with frequent co-infection of HHV-6 and HHV-7, and frequent association with EBV. In contrast to EBV, beta-herpes viruses are therefor e unlikely to have a role in the aetiology of HD. Rather, the presence of t hese viruses seems to reflect impaired immunological surveillance. (C) 2000 Elsevier Science Ltd. All rights reserved.