Expression of intercellular adhesion molecule-I in C6 glioma cells is up-regulated by thyroid hormone

ICAM-I is a cell surface adhesion glycoprotein playing an essential role in inflammatory responses. We have investigated the effects of the thyroid ho rmone T3 on the expression of the ICAM-I gene in C6 glioma cells. In these cells, T3 stimulated the ICAM-I protein expression significantly after 24 h of treatment. The induction of ICAM-I by cytokines such as interleukin I b eta or tumour necrosis factor TNF as well as by lipopolysaccharide or T3 ca n be suppressed by the two antiinflammatory compounds dexamethasone and par thenolide. The C6 glioma cell line could then be a useful model for studyin g the effect of T3 hormone on the expression of specific genes in glial cel ls, especially genes involved in lymphocyte-glial cell interactions. NeuroR eport 11:2855-2860 (C) 2000 Lippincott Williams & Wilkins.