P53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus

Authors
Djebaili, M Rondouin, G Baille, V Bockaert, J
Citation
M. Djebaili et al., P53 and Bax implication in NMDA induced-apoptosis in mouse hippocampus, NEUROREPORT, 11(13), 2000, pp. 2973-2976
Citations number
22
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NEUROREPORT
ISSN journal
09594965 → ACNP
Volume
11
Issue
13
Year of publication
2000
Pages
2973 - 2976
Database
ISI
SICI code
0959-4965(20000911)11:13<2973:PABIIN>2.0.ZU;2-0
Abstract
Seven days after in vivo intrahippocampal administration of NMDA, 3'-OH DNA fragmentations and Bar protein expression were detected in hippocampal neu rons of p53+/+ but not p53-/- transgenic mice. Interestingly, neurons showi ng pycnosis, an early apoptotic phenomena, were present in all genotypes. T hese results confirm that apoptotic 3'OH DNA fragmentations and Bar protein induction during NMDA-induced apoptosis in adult hippocampal neurons are p 53 dependent. NeuroReport 11:2973-2976 (C) Lippincott Williams & Wilkins.