Conduction velocity of the human spinothalamic tract as assessed by laser evoked potentials

To study the conduction velocity of the spinothalamic tract (STT) we delive red CO2 laser pulses, evoking pinprick sensations, to the skin overlying th e vertebral spinous processes at different spinal levels from C5 to T10 and recorded evoked potentials (LEPs) in 15 healthy human subjects. These stim uli yielded large-amplitude vertex potentials consisting of a negative wave at a peak latency of about 200 ms followed by a positive wave at a peak la tency of about 300 ms. The mean conduction velocity of the STT was 21 m/s, i.e. higher than the reported velocity of the corresponding primary sensory neurons (type II AMH). Because dorsal stimulation readily yields reproduci ble brain LEPs, we expect this technique to be useful as a diagnostic tool for assessing the level of spinal cord lesions. NeuroReport 11:3029-3032 (C ) 2000 Lippincott Williams & Wilkins.