Primary placement of a titanium motility post in a porous polyethylene orbital implant - Animal model with quantitative assessment of fibrovascular ingrowth and vascular density
Wc. Hsu et al., Primary placement of a titanium motility post in a porous polyethylene orbital implant - Animal model with quantitative assessment of fibrovascular ingrowth and vascular density, OPHTHAL PL, 16(5), 2000, pp. 370-379
Purpose: To determine whether a Medpor porous polyethylene orbital implant,
at the time of initial orbital implant surgery, will tolerate the insertio
n of a titanium screw on the anterior surface of the implant.
Methods: Twelve New Zealand white rabbits were enucleated and implanted wit
h a porous polyethylene orbital implant. At the time of enucleation, the po
rous polyethylene orbital implants were drilled, and titanium motility coup
ling posts were inserted. The motility coupling posts were inserted at two
projection heights (2 or 3 mm) and either covered within Tenon capsule/conj
unctiva (eight implants) or left exposed (four implants). Rabbits were kill
ed at 6 or 12 weeks. Clinical tissue tolerance, histologic response to the
motility coupling post, and vascular density of the porous polyethylene orb
ital implant were evaluated.
Results: The motility coupling posts were well tolerated, and extrusion or
migration of the motility coupling post did not occur. The average percenta
ge cross-sectional area of the implant occupied by fibrovascular tissue at
6 and 12 weeks was 76.3% and 97.5%, respectively. In comparing the vascular
density (number of vessels per square millimeter) in the porous polyethyle
ne orbital implant within a 1-mm zone immediately surrounding the motility
coupling post, no significant difference between this zone and the vascular
density found within its entire corresponding annulus was found at either
6 or 12 weeks.
Conclusions: During the 6- and 12-week observation periods, all implanted m
otility coupling posts demonstrated favorable tissue tolerance and stable i
nterfaces with surrounding tissues. The extent of fibrovascular tissue ingr
owth and vascular density verify that initial screw insertion does not adve
rsely affect the healing process after porous polyethylene orbital implant
implantation. Thus, primary placement of the motility coupling post may obv
iate the need for a secondary surgical procedure.