Multifocal eosinophilic granuloma of the jaw: Long-term follow-up of a novel intraosseous corticoid treatment for recalcitrant lesions

Eosinophilic granuloma of the jaws is a rather benign and localized form of Langerhans' cell histiocytosis. Treatment is usually required in larger le sions that cause local pain and swelling and pose the risk of spontaneous f ractures. There are several accepted forms of treatment, which include surg ery, radiation therapy, systemic and local therapy with corticoids, and sys temic chemotherapy. No studies exist that compare the effectiveness of thes e treatment modalities. We report a novel therapeutic regimen that uses rep eated intraosseous injections of triamcinolone-1 16 alpha 21-diacetat, a sy nthetic corticoid, which led to a rapid, complete, and durable treatment. T he patient had a multilocal eosinophilic granuloma of the mandible in which radiation therapy, systemic corticoid therapy, and systemic chemotherapy h ad failed.