Efficient synthesis of butenolide-medium ring ether hybrids by a [3+2] cyclization-ring-closing metathesis strategy

Authors
Langer, P Eckardt, T Stoll, M
Citation
P. Langer et al., Efficient synthesis of butenolide-medium ring ether hybrids by a [3+2] cyclization-ring-closing metathesis strategy, ORG LETT, 2(19), 2000, pp. 2991-2993
Citations number
53
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
2
Issue
19
Year of publication
2000
Pages
2991 - 2993
Database
ISI
SICI code
1523-7060(20000921)2:19<2991:ESOBRE>2.0.ZU;2-C
Abstract
GRAPHICS A new strategy for the synthesis of bicyclic gamma-alkylidenebutenolides, b utenolide-medium ring ether hybrids, is reported which involves Me3SiOTf-ca talyzed cyclization of 1,3-bis(trimethylsilyloxy)-1,3 butadienes with oxaly l chloride, Mitsunobu reaction, and subsequent ring-dosing metathesis.