Contamination of dipeptide by polymer stabilizers leached from gloves and packaging during scale-up

Authors
Sano, T Senzaki, H Sugaya, T Kasai, M
Citation
T. Sano et al., Contamination of dipeptide by polymer stabilizers leached from gloves and packaging during scale-up, ORG PROC R, 4(5), 2000, pp. 349-352
Citations number
6
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC PROCESS RESEARCH & DEVELOPMENT
ISSN journal
10836160 → ACNP
Volume
4
Issue
5
Year of publication
2000
Pages
349 - 352
Database
ISI
SICI code
1083-6160(200009/10)4:5<349:CODBPS>2.0.ZU;2-5
Abstract
In dipeptide production, it was observed that a water solution of a peptide became turbid. The origin of turbidity was monitored and identified by LC- MS analysis. The impurities, derived from natural rubber gloves, and polyet hylene bags caused the turbidity when the wet cake of the peptide contacted them.