Conformational diffusion and helix formation kinetics

Authors
Hummer, G Garcia, AE Garde, S
Citation
G. Hummer et al., Conformational diffusion and helix formation kinetics, PHYS REV L, 85(12), 2000, pp. 2637-2640
Citations number
36
Categorie Soggetti
Physics
Journal title
PHYSICAL REVIEW LETTERS
ISSN journal
00319007 → ACNP
Volume
85
Issue
12
Year of publication
2000
Pages
2637 - 2640
Database
ISI
SICI code
0031-9007(20000918)85:12<2637:CDAHFK>2.0.ZU;2-E
Abstract
The lime, temperature, and sequence dependences of helix formation kinetics of fully atomistic peptide models in explicit solvent are described quanti tatively by a diffusive search within the coil state with barrierless trans itions into the helical state. Conformational diffusion leads to nonexponen tial kinetics and jump-width dependences in temperature jump experiments.