Bioanalytical applications of 'fast chromatography' to high-throughput liquid chromatography/tandem mass spectrometric quantitation

Authors
Romanyshyn, L Tiller, PR Hop, CECA
Citation
L. Romanyshyn et al., Bioanalytical applications of 'fast chromatography' to high-throughput liquid chromatography/tandem mass spectrometric quantitation, RAP C MASS, 14(18), 2000, pp. 1662-1668
Citations number
11
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
ISSN journal
09514198 → ACNP
Volume
14
Issue
18
Year of publication
2000
Pages
1662 - 1668
Database
ISI
SICI code
0951-4198(2000)14:18<1662:BAO'CT>2.0.ZU;2-C
Abstract
A fast chromatographic separation approach that enables rapid method develo pment for high-throughput sample quantification is discussed. This approach has been used to analyze samples from various biological matrices. Data ar e presented from in vivo pharmaokinetic studies (plasma) and in vitro drug metabolism and transport studies (hepatic microsomes, hepatocytes, and Caco -2 cells). Copyright (C) 2000 John Wiley & Sons, Ltd.