A. Gurgey et al., PORTAL-VEIN THROMBOSIS IN ASSOCIATION WITH FACTOR-V-LEIDEN MUTATION IN A PATIENT WITH HEPATOCELLULAR-CARCINOMA, Medical and pediatric oncology, 29(3), 1997, pp. 224-225
We report a case of hepatocellular carcinoma associated with portal ve
in thrombosis. Analysis of whole cellular DNA demonstrated heterozygos
ity for the factor V Leiden mutation. The patient also had marked prot
ein C deficiency. The presence of the mutation associated with protein
C deficiency may increase the risk of thrombosis in this patient with
hepatocellular carcinoma. (C) 1997 Wiley-Liss, Inc.