Microbiological transformations. Part 46: Preparation of enantiopure (S)-2-pyridyloxirane via epoxide hydrolase-catalysed kinetic resolution

Authors
Genzel, Y Archelas, A Broxterman, QB Schulze, B Furstoss, R
Citation
Y. Genzel et al., Microbiological transformations. Part 46: Preparation of enantiopure (S)-2-pyridyloxirane via epoxide hydrolase-catalysed kinetic resolution, TETRAHEDR-A, 11(15), 2000, pp. 3041-3044
Citations number
29
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
15
Year of publication
2000
Pages
3041 - 3044
Database
ISI
SICI code
0957-4166(20000811)11:15<3041:MTP4PO>2.0.ZU;2-S
Abstract
The hydrolytic kinetic resolution (HKR) of 2-pyridyloxirane is described, u sing the overexpressed epoxide hydrolase from the filamentous fungus Asperg illus niger. This allows the preparation of the (S)-enantiomer of this prod uct in enantiopure form (ee > 99%), which could not be obtained using conve ntional chemical methods. (C) 2000 Published by Elsevier Science Ltd.