D. Mutimer et al., Lamivudine without HBIg for prevention of graft reinfection by hepatitis B: Long-term follow-up, TRANSPLANT, 70(5), 2000, pp. 809-815
Background. This open, multicenter study was conducted to evaluate the effi
cacy and safety of lamivudine prophylaxis given to chronic hepatitis B viru
s(HBV) infected patients before and after orthotopic liver transplantation
(OLT), We now present long-term data that follow our previous short-term re
port.
Methods. Twenty-three patients were treated with lamivudine (100 mg orally,
daily); 13 (57%), were serum HBV DNA positive (Abbott Genostics, Abbott La
boratories, Chicago, IL) at study entry. Patients received lamivudine for a
t least 4 weeks before OLT, and for up to 50 months (median 25 months) afte
r OLT.
Results. Of the 23 treated patients, 17 survived to undergo OLT, Eleven pat
ients (65%) survived up to 4 years (median 36 months) after OLT. One of the
survivors stopped lamivudine because of a possible adverse reaction 9 mont
hs post-OLT, and prophylaxis with HBV immune globulin was then established.
Ten survivors continue lamivudine, Eight long-term survivors have normal l
iver function without evidence of HBV reinfection. Of the 17 transplanted p
atients, 6 died. Four patients died (3 days to 5 months post-OLT) without e
vidence of graft reinfection. Two further patients died at 19 and 23 months
post-OLT from graft failure. Both patients had YMDD variant detected at 12
months post-OLT, Two other patients with YMDD-variant HBV remain alive on
lamivudine, 9 and 15 months after development of the variant.
Conclusions. Lamivudine, given before and after OLT, prevents significant g
raft reinfection for the majority of treated patients. The study has also s
hown that lamivudine is extremely well tolerated by liver failure patients
and for a prolonged period after transplantation.