Genetics of heart development

Authors
Chen, JN Fishman, MC
Citation
Jn. Chen et Mc. Fishman, Genetics of heart development, TRENDS GEN, 16(9), 2000, pp. 383-388
Citations number
68
Categorie Soggetti
Molecular Biology & Genetics
Journal title
TRENDS IN GENETICS
ISSN journal
01689525 → ACNP
Volume
16
Issue
9
Year of publication
2000
Pages
383 - 388
Database
ISI
SICI code
0168-9525(200009)16:9<383:GOHD>2.0.ZU;2-R
Abstract
The genes that drive heart-cell differentiation in vertebrates and Drosophi la are similar, even though the Drosophila 'heart' is a simple tube and the vertebrate heart is a multichambered physiologically complex organ. Mutati onal analysis in mice and, as particular focus of this review, in zebrafish , reveals the additional genes brought into play to fashion these evolution arily 'new' organotypic components.