Integrin and ECM functions - roles in vertebrate development

The analysis of mutant mice is bringing navel insights on the role of extra cellular matrix (ECM) and integrin receptors during a variety of physiologi cal processes, including embryonic development. The requirement of these ad hesion molecules in epithelial morphogenesis or histogenesis in organs such as kidneys and lungs, in limbs, and in the development of mesoderm and the nervous system has been unraveled by the study of single or compound mutan ts. Their role in tissue integrity has also been highlighted. Models have b een produced that should prove very useful in defining the cellular mechani sms and the functions of integrins and ECM signaling cascades in vivo.