Nuclear, biological and chemical (NBC) terrorism countermeasures are a majo
r priority with municipalities, healthcare providers, and the federal gover
nment. Significant resources are being invested to enhance civilian domesti
c preparedness by conducting education at every response level in anticipat
ion of a NBC terroristic incident. The key to a successful response, in add
ition to education, is integration of efforts as well as thorough communica
tion and understanding the role that each agency would play in an actual or
impending NBC incident. In anticipation of a NBC event, a regional counter
-terrorism task force was established to identify resources, establish resp
onsibilities and coordinate the response to NBC terrorism. Members of the t
ask force included first responders, hazmat, law enforcement (local, region
al, national), government officials, the health department, and the regiona
l poison information center. Response protocols were developed and educatio
n was conducted, culminating in all members of the response task force beco
ming certified NBC instructors. The poison center participated actively in
3 incidents of suspected biologic and chemical terrorism: an alleged anthra
x-contaminated letter sent to a women's health clinic; a possible sarin gas
release in a high school; and a potential anthrax/ebola contamination inci
dent at an international airport. All incidents were determined hoaxes. The
regional response plan establishes the poison information center as a comm
on repository for all cases in a biological or chemical incident. The poiso
n center is one of several critical components of a regional counterterrori
sm response force. It can conduct active and passive toxicosurveillance and
identify sentinel events. To be responsive, the poison center staff must b
e knowledgeable about biological and chemical agents. The development of ba
sic protocols and a standardized staff education program is essential. The
use of the RaPiD-T (R-recognition, P-protection, D-detection, T-triage/trea
tment) course can provide basic staff education for responding to this impo
rtant but rare consultation to the poison center.