Persistent pulmonary hypertension after maternal naproxen ingestion in a term newborn: A case report

Constricting effect of indomethacin on the ductus arteriosus of the fetus i s well known. The fetal effects of other nonsteroid anti-inflammatory drugs (NSAIDs) like naproxen are not well reported. We report here a case of a 3 790-g term neonate who developed persistent pulmonary hypertension after bi rth with a closed ductus arteriosus. The mother admitted to taking naproxen sodium immediately prior to the birth of the infant. The course of illness was progressively better on conservative management. Like indomethacin, ot her NSAIDs can also cause premature closure of fetal ductus arteriosus, pul monary hypertension, acid life-threatening problems to the neonate, Patient education regarding over-the-counter pain medication during pregnancy shou ld be emphasized.