The effects of KRN5500, a spicamycin derivative, on neuropathic and nociceptive pain models in rats

We studied the effects of a spicamycin derivative, KRN5500, on two animal m odels of neuropathic pain (Chung and Bennett models) and a nociceptive pain model by using Complete Freund's adjuvant. After the establishment of mech anical allodynia by using the previously mentioned models, a single intrape ritoneal injection of KRN5500 produced significant attenuation of mechanica l allodynia in both neuropathic pain models. However, this effect was not o bserved in rats that had a nociceptive injury (Complete Freund's adjuvant). Furthermore, this experimental drug did not alter the mechanical pain thre shold (by using von Frey filament test) on normal, uninjured rats. We have demonstrated that KRN5500 may have value in the treatment of neuropathic pa in.